Holista NMN 150mg 60 Vcap

NMN is a bioavailable precursor to nicotinamide adenine dinucleotide (NAD+), a key coenzyme needed for over 500 enzymatic reactions. As many of these enzymatic reactions are related to cellular metabolism, aging, inflammation, circadian rhythm, mitochondrial respiration, glycolysis, and DNA repair, NAD+ is considered critical to human health and longevity. NAD+ is also needed for the expression of sirtuins, enzymes with numerous cellular regulatory effects particularly important for inflammation, DNA repair, and energy metabolism. Considerable research shows a decline in NAD+ and sirtuin expression with aging, leading to an impairment of mitochondrial function and biogenesis and increased oxidative damage, driving the aging process itself as well as many diseases associated with aging, including cardiovascular and metabolic diseases. NMN has been shown to significantly increase blood levels of NAD+ in human clinical trials, in part because it is only one enzymatic step from NAD+. Controlled clinical trials have demonstrated multiple benefits of NMN supplementation, including improvements in insulin sensitivity and signalling among women with impaired glucose metabolism, as well as aerobic capacity in healthy runners, and reduced drowsiness and improved sit-to-stand in older adults. Indicative of its potential to address aging pathways by restoring NAD+ levels, NMN supplementation for 12 weeks found a trend toward reduced arterial stiffness, an aging-related independent risk factor for cardiovascular and metabolic diseases.